Results of a new cognitive method in rats on the Morris water maze used in modeling experimental Alzheimer's disease

Materials and methods The CA3 neurons were chemically lesioned by intracerebrally administration of NaN3 in doses of 8 and 16 mg/ml. To examine learning functions Morris maze was used. During acquisition trials animals had to find a black platform within 120 s. We measured the “escape latency"(msec). Detailed histopathology of brain was performed at the termination of the study. Learning function was measured after 7 days of ic. treatment.